IGF-1 LR3

IGF-1 LR3 (Long R3 IGF-1) is a recombinant, modified analogue of insulin-like growth factor 1 (IGF-1) belonging to the class of peptide growth factors. It differs from natural IGF-1 by an extended N-terminal chain and an arginine substitution at position three, which give it a longer half-life and lower affinity for IGF-binding proteins (IGFBPs). In in vitro models it is studied as an IGF-1 receptor (IGF-1R) agonist that activates tyrosine kinase signalling and the downstream PI3K/Akt and MAPK/ERK signalling pathways. This information is provided for research context only.

Because of its reduced affinity for IGF-binding proteins, IGF-1 LR3 is used in laboratories as a stable tool for studying the mechanisms of cell proliferation, differentiation and protein synthesis in cell cultures. In vitro models monitor IGF-1R receptor signalling dynamics and the activation of the PI3K/Akt/mTOR and MAPK/ERK pathways. Such models include cultures of myoblasts, fibroblasts and other cell lines. All these processes are studied exclusively under in vitro conditions.

The product is supplied as a high-grade laboratory lyophilised powder. Each vial contains 1 mg of IGF-1 LR3. For laboratory use, the powder is dissolved in bacteriostatic water, which is sold separately. Dissolve by swirling the vial slowly until the solution is clear; do not shake the vial, so as not to damage the peptide structure. The reconstitution volume is chosen according to the concentrations required for the study.

Keep the unopened vial of dry powder in a refrigerator (+2 to +8 °C), or in a freezer (−20 °C) for longer storage, protected from light. Once reconstituted in bacteriostatic water, keep the solution refrigerated and use it within the time set out in your research protocol. Avoid repeated thaw–freeze cycles to maintain the stability of the compound.

In in vitro scientific research, IGF-1 LR3 is often used in cell culture media together with other growth factors, for example to study synergy with factors used in myoblast differentiation or proliferation models. It is also used as a reference tool for receptor signalling, compared with natural IGF-1 or insulin in studies of cellular response. The combination depends on the specific laboratory protocol and cell line; no doses for humans or animals are given.

Absolutely not. This product is sold exclusively for laboratory research and scientific experiments. It is not intended for human or animal consumption and is not a medicine, dietary supplement or cosmetic product.