SNAP-8

SNAP-8 (acetyl octapeptide-3) is a synthetic eight-amino-acid peptide (sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) belonging to the group of SNARE protein-targeting peptides. Its sequence is related to the N-terminal region of the SNAP-25 protein. In in vitro research models, the compound is studied for its interaction with SNARE complex proteins, especially SNAP-25, which take part in cellular vesicle docking and externalisation. Cellular and cell-free systems are used to examine how the peptide may competitively modulate the assembly of this complex. This information is provided for research context only and is not an instruction for use.

In the laboratory, SNAP-8 is used as a molecular tool for studying the mechanisms of SNARE complex assembly. In vitro models examine the dynamics of vesicle docking and externalisation, the interaction of SNAP-25 protein fragments within the complex, and structure–activity relationships (SAR) between peptides matching the sequence. Such experiments are carried out only in the context of cellular and cell-free biochemical systems, with the aim of understanding molecular signalling pathways. All studies are limited to a laboratory, in vitro setting.

The product is supplied as a lyophilised powder. Each vial contains 10 mg of the active substance – acetyl octapeptide-3 (SNAP-8). Purity ≥99% (HPLC). For laboratory work, the powder is usually reconstituted in bacteriostatic water (sold separately) by gently swirling the vial until a uniform solution forms – do not shake vigorously. All amounts and concentrations are set within the experimental plan.

Keep the unopened vial of dry lyophilised powder in a refrigerator (+2 to +8 °C), protected from light. For longer storage, a freezer (−20 °C) is recommended. Keep the reconstituted solution (dissolved in bacteriostatic water) refrigerated and use it within the time set out in your research protocol. Avoid repeated thaw–freeze cycles.

In in vitro research, SNAP-8 is most often studied in the context of models of the SNARE complex and the SNAP-25 protein, together with other SNARE-targeting peptides of the same class (e.g. derivatives of the acetyl hexapeptide sequence), comparing structure–activity relationships. Methodologically, it is combined with biochemical binding assays and systems for analysing cellular vesicle externalisation. The specific combination depends on the aim of the study; no doses or usage instructions are given.

Absolutely not. This product is sold exclusively for laboratory research and scientific experiments. It is not intended for human or animal consumption and is not a medicine, dietary supplement or cosmetic product.