HGH – Somatropin

Somatropin is recombinant human growth hormone (rhGH) – a protein with a 191-amino-acid polypeptide chain that is structurally identical to somatotropin synthesised naturally in the pituitary gland. It is a protein-based research material belonging to the growth hormone class. Its main mechanism of action in in vitro models: the molecule acts as a ligand of the growth hormone receptor (GHR) – once bound, it causes receptor dimerisation and activates the intracellular JAK2/STAT5 signalling pathway. The molecule is stabilised by two disulfide bonds. This information is provided for research context only and is not an instruction for use.

In cell cultures and other in vitro models, somatropin is used for research in endocrinology and cell signalling pathways. It is used to analyse GHR receptor activation, engagement of the JAK2/STAT5 pathway and expression along the IGF-1 axis, as well as the regulation of protein synthesis and metabolic genes. Because of its two disulfide bonds, the molecule is also of interest in research on structural integrity and protein stability under laboratory conditions. All these processes are studied in vitro only, with no connection to use in humans or animals.

The product is supplied as a lyophilised (dry) powder. Each vial contains 24 IU of somatropin (recombinant growth hormone) of ≥99% purity (HPLC). For laboratory preparation, the powder is reconstituted with bacteriostatic water, which is sold separately. The solvent is run slowly down the side of the vial, and the vial is swirled carefully without shaking so that the protein chain does not denature.

Keep unopened vials of dry powder in a refrigerator at +2 to +8 °C, protected from light. A freezer (−20 °C) is suitable for longer storage. Keep the reconstituted solution (dissolved in bacteriostatic water) refrigerated and use it within the time set out in your research protocol. Proper storage helps maintain reproducible material uniformity between studies.

In signalling pathway research, somatropin is most often studied together with IGF-1 (insulin-like growth factor), because IGF-1 expression is the main marker of GHR activation in in vitro models. Methodologically, it is combined with JAK2/STAT5 pathway markers and GHR receptor expression systems (e.g. GHR-expressing cell lines, hepatocyte cultures) in which the specificity of the receptor response is assessed. This is a laboratory modelling context only – no dosing or usage instructions are given.

Absolutely not. This product is sold exclusively for laboratory research and scientific experiments. It is not intended for human or animal consumption and is not a medicine, dietary supplement or cosmetic product.