Semax

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the adrenocorticotropic hormone fragment ACTH(4–10). The Pro-Gly-Pro chain attached to the ACTH(4–7) sequence gives the molecule greater resistance to enzymatic degradation in laboratory models, but the molecule itself has no hormonal activity. In the research context it is described as a ligand of the melanocortin system and a neuropeptide whose main mechanism of interest is the modulation of neurotrophic factor expression, especially BDNF and its receptor TrkB, and the related signalling pathways in neuronal cultures and other in vitro models. This information is provided for research context only and does not describe effects on humans or animals.

In laboratory systems, this compound is used to study neurotrophic signalling – primarily the modulation of BDNF and TrkB receptor expression and the associated signalling pathways. The peptide’s interaction with dopaminergic and serotonergic systems and its investigational neuroprotective properties in cellular stress models are also studied. For example, work by Dolotov and colleagues (Brain Research, 2006) documented how Semax regulates BDNF and trkB expression in a laboratory model. All such observations describe phenomena under research conditions, not effects on the human or animal body.

The product is supplied as a lyophilised (freeze-dried) powder. Each vial contains 10 mg of Semax of ≥99% purity (HPLC), analytically verified and produced in consistent batches. For laboratory handling, the powder is usually dissolved in bacteriostatic water, which is sold separately. The solvent is run slowly down the side of the vial, and the powder is swirled gently until fully dissolved – shaking is not recommended, as it may break down the peptide.

Keep the unopened vial of dry powder in a refrigerator at +2 to +8 °C. For longer storage, use a freezer at about −20 °C, always protected from light. Once reconstituted in bacteriostatic water, keep the solution chilled in the refrigerator and use it within the time set out in your research protocol. Avoid repeated thaw–freeze cycles to preserve the stability of the material under research conditions.

In the research context, Semax is most often studied in neuronal cultures and other in vitro models together with markers of neurotrophic signalling – assessing BDNF and TrkB receptor expression and phosphorylation. When studying its interaction with neurotransmitter systems, it is combined with analysis of dopaminergic and serotonergic pathways, and in neuroprotection models with systems for inducing cellular or oxidative stress. Such combinations describe only the design of laboratory experiments and do not include any dosing or usage instructions.

Absolutely not. This product is sold exclusively for laboratory research and scientific experiments. It is not intended for human or animal consumption and is not a medicine, dietary supplement or cosmetic product.